Serotonin Syndrome in the News

MedlinePlus, a service of the US National Library of Medicine and the National Institutes of Health defines Serotonin Syndrome:

Serotonin syndrome is a life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells.

And cites the cause:

Serotonin Syndrome most often occurs when two drugs that affect the body's level of serotonin are taken together at the same time. The drugs cause too much serotonin to be released or to remain in the brain area.

An example of this is taking a Selective Serotonin Receptor Agonist also known as a Triptan while you are taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin and Norepinephrine Reuptake Inhibitor (SNRI). In other words using Imitrex aka Sumatriptan (a Triptan) while taking Prozac (an SSRI) or Cymbalta (an SNRI) can cause Serotonin Syndrome.

It is believed that changes in serotonin is involved in causing Migraine attacks. More about it can be found HERE. This information has been around for a while so.....

Why is Serotonin Syndrome in the news?

In the May 15 issue of the New England Journal of Medicine, Georgetown University researchers and the U.S. Food and Drug Administration detail 11 cases of Serotonin Syndrome associated with the use of triptans alone that were reported to the FDA's Adverse Event Reporting System (AERS)."

Offie Soldin, an associate professor of medicine and oncology at Georgetown University Medical Center and the study's lead author said:

The FDA has already issued an advisory and an alert that when triptans are used in combination with SSRIs, there is a possibility of serotonin syndrome. The news here is that it doesn't have to be in combination, triptans alone can cause serotonin syndrome

Soldin also stressed that this is very rare and unlike to happen saying:

...you just need to stop taking the drugs when it does happen. If you're taking these medications and you have strange muscular, mental or hyperactivity symptoms, contact your doctor.

More information can be found in this Washington Post article.

May is Stroke Awareness Month - Do You Know the Warning Signs?

Did you know Migraine increases your Stroke risk? Information regarding the Migraine - Stroke connection can be found in MAGNUM's article Migraines: Myth Vs. Reality:

According to the New England Journal of Medicine, "migraine can sometimes lead to ischemic stroke and stroke can sometimes be aggravated by or associated with the development of migraine." Twenty-seven percent of all strokes suffered by persons under the age of 45 are caused by Migraine. Stroke is the third leading cause of death in this country. In addition, twenty-five percent of all incidents of cerebral infarction were associated with Migraines, according to the Mayo clinic. Most recently the British Medical Journal reported that after evaluating 14 major Migraine & stroke studies in the U.S. and Canada that Migraineurs are 2.2 times greater risk for stroke than the non-migraine population. That risk goes up to a staggering 8 times more stroke risk for women Migraineurs on the pill!

Can you recognize ALL five correct Stroke symptoms? Can you identify an incorrect Stroke symptom? Do you know when you need to call 9-1-1 when someone appears to be having a Stroke? If you answered "no", you're not alone.

Results of the 2005 Behavioral Risk Factor Surveillance System (BRFSS) survey that was used in 13 states and the District of Columbia (DC) to examine public awareness of Stroke warning symptoms and the importance of seeking emergency care were examined in this week's issue of the CDC's Morbidity and Mortality Weekly Report article Awareness of Stroke Warning Symptoms --- 13 States and the District of Columbia, 2005. Out of 71,994 participants only 16.4% of respondents could recognize all five correct symptoms, identify an incorrect symptom and recognize the need to call 9-1-1.

May is Stroke Awareness Month. The National Institute of Neurological Disorders and Stroke (NINDS) developed the Know Stroke, Know the Signs. Act in Time campaign to educate the public about recognizing Stroke symptoms. If you don't know these five symptoms, take the time to learn them. If you already know them, teach them to someone else. At the very least, print them and attach them to your refrigerator so that your family can learn them.

• Sudden numbness or weakness of the face, arm, or leg (especially on one side of the body)
• Sudden confusion, trouble speaking or understanding speech
• Sudden trouble seeing in one or both eyes
• Sudden trouble walking, dizziness, loss of balance or coordination
• Sudden severe headache with no known cause

These five symptoms can also be found HERE.

The NINDS says you may not realize you're having a stroke and you may not be able to call 9-1-1 on your own. The people around you may not know you're having a Stroke and just think you're confused. Don't waste precious time. Arriving at the hospital within 60 minutes after experiencing symptoms can greatly reduce Stroke damage. If you or someone you know is having a Stroke call 9-1-1 IMMEDIATELY.